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Nestled along the Mississippi River, Cape Girardeau, Missouri, offers a charming blend of history, culture, and natural beauty, making it an ideal travel destination. Visitors can enjoy a variety of accommodations, from cozy bed-and-breakfasts to modern hotels, ensuring a comfortable stay for every traveler. The downtown area is a popular choice for lodging, providing easy access to the city's vibrant arts scene, unique shops, and delightful dining options.
Among the top attractions in Cape Girardeau are the historic Trail of Tears State Park, the Cape River Heritage Museum, and the stunning views from the Bill Emerson Memorial Bridge. The city is also home to Southeast Missouri State University, which adds a youthful energy and hosts numerous cultural events throughout the year.
Whether you're exploring the scenic riverfront or delving into the rich local history, Cape Girardeau promises a memorable experience for all visitors.
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Hotel in Cape Girardeau · 0.24 mi from centre
9.4
394 reviews
Breakfast available
Located in Cape Girardeau, Courtyard by Marriott Cape Girardeau Downtown is within a 15-minute walk of Shawnee National Forest and eDen Spa & Salon. This hotel is 0.7 mi (1.1 km) from Isle Casino Cape Girardeau and 0.7 mi (1.2 km) from Southeast Missouri State University.

Hotel in Cape Girardeau · 3.15 mi from centre
9.6
687 reviews
Breakfast available
With a stay at Hampton Inn Cape Girardeau I 55 East in Cape Girardeau, you'll be within a 10-minute drive of Shawnee National Forest and Mississippi River. This hotel is 0.5 mi (0.8 km) from Saint Francis Medical Center and 2.3 mi (3.7 km) from Saint Francis Healthcare System.

Hotel in Cape Girardeau · 3.16 mi from centre
8.0
728 reviews
With a stay at Candlewood Suites Cape Girardeau by IHG in Cape Girardeau, you'll be within a 10-minute drive of Shawnee National Forest and Mississippi River. This hotel is 1.3 mi (2 km) from Saint Francis Medical Center and 3 mi (4.9 km) from Fort D Historic Site.

Hotel in Cape Girardeau · 4.03 mi from centre
7.0
544 reviews
Breakfast available
With a stay at Quality Inn in Cape Girardeau, you'll be within a 10-minute drive of Shawnee National Forest and Mississippi River. This hotel is 0.6 mi (1 km) from Saint Francis Healthcare System and 0.8 mi (1.4 km) from Cape Splash Family Aquatic Center.

Apartment in Cape Girardeau · 0.19 mi from centre
10.0
1 review
Both free Wifi and private parking are accessible at Downtown Cape 2 Bdrm 2 Bath Apt, Cozy & Walkable free of charge.
The apartment features 2 bedrooms, a fully equipped kitchen with a dishwasher and an oven, a washing machine, and 2 bathrooms with a hair dryer. Towels and bed linen are offered in the apartment. For added privacy, the accommodation features a private entrance.
Cape Girardeau Regional Airport is 6.8 miles from the property.

Hotel in Cape Girardeau · 0.51 mi from centre
9.2
136 reviews
Breakfast available
When you stay at The Riverview in Cape Girardeau, you'll be in the entertainment district, within a 15-minute walk of Shawnee National Forest and Mississippi River. This casino hotel is 0.1 mi (0.2 km) from Riverfront Park and 0.1 mi (0.2 km) from Isle Casino Cape Girardeau.

Hotel in Cape Girardeau · 0.96 mi from centre
9.6
6 reviews
With a stay at Rockwood Inn in Cape Girardeau, you'll be within a 5-minute drive of Shawnee National Forest and Mississippi River. This hotel is 0.2 mi (0.4 km) from Southeast Missouri State University and 0.7 mi (1.2 km) from Show Me Center.

Hotel in Cape Girardeau · 3.19 mi from centre
9.2
79 reviews
Breakfast available
With a stay at Fairfield Inn & Suites by Marriott Cape Girardeau in Cape Girardeau, you'll be within a 10-minute drive of Shawnee National Forest and Mississippi River. This hotel is 1.2 mi (1.9 km) from Saint Francis Medical Center and 2.8 mi (4.5 km) from Southeast Missouri Hospital.

Hotel in Cape Girardeau · 3.22 mi from centre
9.4
952 reviews
Breakfast available
When you stay at Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG in Cape Girardeau, you'll be near the airport, within a 10-minute drive of Shawnee National Forest and Mississippi River. This spa hotel is 0.5 mi (0.8 km) from Saint Francis Medical Center and 2.4 mi (3.8 km) from Cape Splash Family Aquatic Center.

Hotel in Cape Girardeau · 5.37 mi from centre
Breakfast available
With a stay at Tru By Hilton Cape Girardeau in Cape Girardeau, you'll be within a 10-minute drive of Shawnee National Forest and Mississippi River. This hotel is 0.7 mi (1.2 km) from Cape Girardeau Conservation Nature Center and 2 mi (3.2 km) from Saint Francis Healthcare System.

Hotel in Missouri, Jackson · 6.10 mi from centre
8.8
503 reviews
Breakfast available
When you stay at La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau in Jackson, you'll be in the business district, within a 15-minute drive of Shawnee National Forest and Mississippi River. This hotel is 1.5 mi (2.3 km) from Cape Girardeau Conservation Nature Center and 2 mi (3.3 km) from Lazy L Safari Park.

Hotel in Missouri, Jackson · 6.10 mi from centre
8.2
679 reviews
Breakfast available
With a stay at Comfort Suites Jackson-Cape Girardeau, you'll be centrally located in Jackson, within a 15-minute drive of Shawnee National Forest and Mississippi River. This hotel is 1.5 mi (2.5 km) from Cape Girardeau Conservation Nature Center and 2 mi (3.2 km) from Lazy L Safari Park.

Motel in Ozarks, Jackson · 9.31 mi from centre
7.6
375 reviews
Located in Jackson, Town House Inn is within a 15-minute drive of Shawnee National Forest and Mississippi River. This motel is 1.5 mi (2.4 km) from Litz Park and 4.3 mi (6.9 km) from Lazy L Safari Park.