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Santa Cruz de la Sierra, commonly known as Santa Cruz, is the largest city in Bolivia and a vibrant travel destination. Nestled on the Pirai River in the eastern Tropical Lowlands, it offers a unique blend of cultural heritage and modernity. Visitors can explore the bustling city center, which is a hub for business and tourism, or relax in the lush surroundings of the Amazon basin. The best neighborhoods to stay include Equipetrol, known for its upscale hotels and dining, and the historic center, where colonial architecture meets lively markets. Top attractions include the stunning Cathedral Basilica of St. Lawrence, the bustling Plaza 24 de Septiembre, and the serene Biocentro Güembé. Whether you're seeking adventure or relaxation, Santa Cruz provides a diverse array of experiences for every traveler.
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Hotel in Santa Cruz · 0.24 mi from centre
9.0
118 reviews
Breakfast available
With a stay at Cosmopolitano Hotel Boutique, you'll be centrally located in Santa Cruz, just a 4-minute walk from Sacred Art Museum and 5 minutes by foot from San Lorenzo Cathedral. This hotel is 0.4 mi (0.6 km) from Artecampo and 0.4 mi (0.7 km) from Guarani Nandereko Nomai Art and Culture Center.

Hotel in Santa Cruz · 0.37 mi from centre
8.4
6 reviews
Breakfast available
With a stay at Lido Hotel, you'll be centrally located in Santa Cruz, just a 5-minute walk from Arenal Park and 6 minutes by foot from Guarani Nandereko Nomai Art and Culture Center. This hotel is 0.5 mi (0.7 km) from La Recova Artisan Walk and 0.5 mi (0.8 km) from Municipal Library.

Hotel in Santa Cruz, Santa Cruz de la Sierra · 0.99 mi from centre
8.1
402 reviews
Breakfast available
Located in Santa Cruz de la Sierra, within 1.2 miles of Sacred Art Museum and 1.6 miles of Metropolitan Cathedral, Prince Hotel provides accommodations with a garden as well as free private parking for guests who drive. With an outdoor swimming pool, the 3-star hotel has air-conditioned rooms with free WiFi, each with a private bathroom. The property has room service, a 24-hour front desk and currency exchange for guests.
At the hotel, each room includes a desk. All rooms come with a safety deposit box, while selected rooms here will provide you with a balcony and others also have city views. All guest rooms in Prince Hotel are equipped with a flat-screen TV and free toiletries.
Buffet and continental breakfast options are available at the accommodation.
Prince Hotel offers a sauna.
24th of September Metropolitan Plaza is 1.9 miles from the hotel, while Arenal Park is 2.4 miles from the property. Viru Viru International Airport is 10 miles away, and the property offers a paid airport shuttle service.

Hotel in Santa Cruz · 1.21 mi from centre
8.8
23 reviews
Breakfast available
A stay at HOTEL OSHO places you in the heart of Santa Cruz, within a 5-minute drive of Santa Cruz de la Sierra Contemporary Art Museum and Municipal Library. This spa hotel is 1.4 mi (2.3 km) from La Recova Artisan Walk and 1.5 mi (2.4 km) from Casa Municipal de Cultura Raúl Otero Reiche.

Hotel in Santa Cruz · 1.53 mi from centre
9.2
105 reviews
Breakfast available
Located in Santa Cruz, TRYP by Wyndham Santa Cruz is in the business district, within a 15-minute walk of Santa Cruz Zoo and Patio Design LifeStyle Center. This hotel is 1.3 mi (2.2 km) from Ventura Mall and 1.7 mi (2.8 km) from Municipal Library.

Hotel in Santa Cruz, Santa Cruz de la Sierra · 1.70 mi from centre
8.0
389 reviews
Breakfast available
Located in the commercial district of Equipetrol, this property offers accommodations with free WiFi access in Santa Cruz de la Sierra. A complimentary buffet breakfast is served daily at LP Equipetrol.
Rooms here are spacious, have wooden floors and are all fitted with a flat-screen TV and a private bathroom. In addition, they have a city view.
At LP Equipetrol guests will find an on-site restaurant, a 24-hour front desk and currency exchange services. Laundry services can be requested for an extra fee. Free private parking is available on site.
The property is located in a tranquil yet strategic position, as guests will find an array of restaurants and commerce a 2-minute walk away. Ventura Shopping Center is a 5-minute walk away.
The city center of Santa Cruz is a 10-minute drive away whereas Viru Viru International Airport is approximately a 30-minute drive away. Shuttle services can be requested for a fee.

Hotel in Santa Cruz · 1.75 mi from centre
8.8
47 reviews
Located in Santa Cruz, Delfines Collection Hotel By Mercure is within a 15-minute walk of Santa Cruz Zoo and Ventura Mall. This hotel is 1 mi (1.7 km) from Patio Design LifeStyle Center and 1.8 mi (2.9 km) from Municipal Library.

Hotel in Santa Cruz · 1.82 mi from centre
7.8
102 reviews
Breakfast available
Located in Santa Cruz, Hotel G is in the business district, within a 5-minute drive of Las Brisas Shopping Center and Santa Cruz Zoo. This hotel is 2 mi (3.2 km) from Municipal Library and 2.1 mi (3.3 km) from Ethno-folkloric Museum.

Hotel in Santa Cruz · 1.88 mi from centre
9.0
220 reviews
Breakfast available
Located in Santa Cruz, Hampton by Hilton Santa Cruz/Equipetrol, Bolivia is in the business district, within a 5-minute drive of Ventura Mall and Santa Cruz Zoo. This luxury hotel is 1.8 mi (2.9 km) from Municipal Library and 2.2 mi (3.6 km) from Las Brisas Shopping Center.

Hotel in Santa Cruz · 1.94 mi from centre
9.4
31 reviews
When you stay at Chairú Eco Hotel in Santa Cruz, you'll be in the business district, within a 5-minute drive of Ventura Mall and Patio Design LifeStyle Center. This hotel is 1.3 mi (2.2 km) from Santa Cruz Zoo and 1.9 mi (3 km) from Parque Ecológico.

Hotel in Santa Cruz · 2.05 mi from centre
8.8
175 reviews
Breakfast available
Located in Santa Cruz, Marriott Santa Cruz de la Sierra Hotel is in the business district, within a 5-minute drive of Ventura Mall and Santa Cruz Zoo. This luxury hotel is 1.2 mi (1.9 km) from Patio Design LifeStyle Center and 2.2 mi (3.5 km) from Municipal Library.

Hotel in Santa Cruz · 3.18 mi from centre
8.6
233 reviews
Located in Santa Cruz, Radisson Hotel Santa Cruz is connected to the convention center, a 4-minute drive from Ventura Mall and 7 minutes from Santa Cruz Zoo. This golf hotel is 3.2 mi (5.2 km) from Guembe Biocenter and 4.1 mi (6.5 km) from Municipal Library.

Aparthotel in Santa Cruz · 4.35 mi from centre
7.8
89 reviews
Breakfast available
Located in Santa Cruz, Terranova Suites is within a 10-minute drive of Las Brisas Shopping Center and Santa Cruz Zoo. This aparthotel is 3.6 mi (5.7 km) from Ventura Mall and 8 mi (12.9 km) from Guembe Biocenter.

Homestay in Santa Cruz, Santa Cruz de la Sierra · 0.29 mi from centre
8.5
31 reviews
Breakfast available
Sarao is a recently renovated homestay in Santa Cruz de la Sierra, near 24th of September Metropolitan Plaza. This homestay offers air-conditioned accommodations with a terrace. The accommodation provides a 24-hour front desk, a shared kitchen, and currency exchange for guests.
With free Wifi, this homestay features a flat-screen TV, a washing machine, and a fully equipped kitchen with an oven and microwave. Towels and bed linen are available in the homestay. The property has an outdoor dining area.
Sightseeing tours are available in the neighborhood.
Popular points of interest near the homestay include Sacred Art Museum, Arenal Park, and Metropolitan Cathedral. Viru Viru International Airport is 9.3 miles from the property.

Homestay in Santa Cruz, Samaipata · 53.04 mi from centre
9.7
347 reviews
Casa Samai Boutique offers accommodations in Samaipata, 5.8 miles from Samaipata Fort. This property offers access to a terrace, free private parking, and free Wifi. The homestay offers garden views and an outdoor fireplace.
Selected rooms will provide you with a fully equipped kitchenette with a fridge and kitchenware. At the homestay, the units have bed linen and towels.
Buffet and continental breakfast options with warm dishes, fruit, and juice are available. Guests can make the most of the warm weather with the property's barbecue facilities.
For guests with children, the homestay provides an indoor play area and a baby safety gate. Guests at Casa Samai Boutique can enjoy hiking nearby, or make the most of the garden.
Viru Viru International Airport is 84 miles away.

Hotel in Santa Cruz, Santa Cruz de la Sierra · 0.05 mi from centre
7.6
47 reviews
Located in Santa Cruz de la Sierra, a few steps from Sacred Art Museum, Pascana Hotel provides accommodations with an outdoor swimming pool, free private parking, a terrace and a restaurant. Featuring a bar, the hotel is close to several noted attractions, around a few steps from Metropolitan Cathedral, a 1-minute walk from 24th of September Metropolitan Plaza and half a mile from Arenal Park. The property has a 24-hour front desk, a shuttle service, room service and free WiFi throughout the property.
The hotel will provide guests with air-conditioned rooms with a closet, an electric tea pot, a safety deposit box, a flat-screen TV and a private bathroom with a shower.
At Pascana Hotel guests are welcome to use a sauna and a hot tub.
Gabriel Rene Moreno Autonomous University is 2.2 miles from the accommodation, while Güembé Biocentre and Guazú Ivaga Park is 2.2 miles away. Viru Viru International Airport is 9.3 miles from the property.

Apartment in Santa Cruz, Santa Cruz de la Sierra · 0.12 mi from centre
9.0
2 reviews
Breakfast available
Comodo Loft en centro historico! is located in Santa Cruz de la Sierra, just 1.7 miles from Gabriel Rene Moreno Autonomous University and 2.1 miles from Güembé Biocentre and Guazú Ivaga Park. The Lomas de Arena National Park is within 8.3 miles of the apartment. Free Wifi is available throughout the property and 24th of September Metropolitan Plaza is a 3-minute walk away.
Featuring city views, the apartment is composed of 1 bedroom and 1 bathroom with a hair dryer and free toiletries. Towels and bed linen are provided in the apartment. For added privacy, the accommodation features a private entrance.
Guests at the apartment will be able to enjoy activities in and around Santa Cruz de la Sierra, like walking tours.
Popular points of interest near Comodo Loft en centro historico! include Sacred Art Museum, Metropolitan Cathedral, and Arenal Park. Viru Viru International Airport is 8.7 miles away.

Guest house in Santa Cruz, Santa Cruz de la Sierra · 0.13 mi from centre
8.0
2 reviews
Hostal Mar Ed offers air-conditioned rooms in Santa Cruz de la Sierra. Guests can go for a swim in the rooftop pool. The guest house provides a sun terrace and a 24-hour front desk.
At the guest house, all units are equipped with a wardrobe, a flat-screen TV, a private bathroom, bed linen, and towels. There's also a fridge, minibar, and a kettle. The rooms are equipped with heating facilities.
Guests at the guest house can enjoy a continental breakfast. There is a coffee shop and bar.
Guests can relax in the garden at the property.
Popular points of interest near Hostal Mar Ed include 24th of September Metropolitan Plaza, Sacred Art Museum, and Metropolitan Cathedral. Viru Viru International Airport is 9.3 miles away, and the property offers a paid airport shuttle service.

Apartment in Santa Cruz, Santa Cruz de la Sierra · 0.13 mi from centre
9.5
6 reviews
Bolivar 130 is a recently renovated apartment in Santa Cruz de la Sierra near Sacred Art Museum. Housed in a building dating back to 2021, this apartment is 1.9 miles from Gabriel Rene Moreno Autonomous University and 2.1 miles from Güembé Biocentre and Guazú Ivaga Park. Lomas de Arena National Park is 8.6 miles from the apartment.
At the apartment complex, all units come with air conditioning and a private bathroom.
Popular points of interest near the apartment include Metropolitan Cathedral, 24th of September Metropolitan Plaza, and Arenal Park. Viru Viru International Airport is 9.3 miles away.

Apartment in Santa Cruz, Santa Cruz de la Sierra · 0.17 mi from centre
8.6
90 reviews
Tradición offers accommodations in Santa Cruz de la Sierra, a 3-minute walk from 24th of September Metropolitan Plaza and 1.7 miles from Güembé Biocentre and Guazú Ivaga Park. This apartment is 2 miles from Gabriel Rene Moreno Autonomous University and 8.6 miles from Lomas de Arena National Park. The apartment provides rooms with air conditioning, free private parking, and free Wifi.
Each unit features a terrace, a fully equipped kitchen with a dishwasher, a dining area, and a flat-screen TV, while the private bathroom includes a shower and free toiletries. A microwave, a fridge, and kitchenware are also provided, as well as a kettle.
Popular points of interest near the apartment include Sacred Art Museum, Arenal Park, and Metropolitan Cathedral. The nearest airport is Viru Viru International Airport, 8.1 miles from Tradición.