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Seneca, nestled in the picturesque Oconee County of South Carolina, offers a charming retreat for travelers seeking a blend of natural beauty and cultural heritage. As the principal city of the Seneca Micropolitan Statistical Area, it provides a welcoming atmosphere with a variety of accommodations to suit every preference. Visitors can explore the historic downtown area, where quaint shops and local eateries offer a taste of Southern hospitality.
For those looking to stay in the best neighborhoods, the areas around Lake Keowee and Lake Hartwell are highly recommended, offering stunning lakeside views and recreational activities. The Seneca Historic District is another prime location, rich with architectural charm and history.
Top attractions include the nearby Blue Ridge Mountains, perfect for hiking and outdoor adventures, and the World of Energy, an educational experience about energy production. Seneca's proximity to Clemson University also makes it a vibrant spot for cultural and sporting events.
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Hotel in Upstate South Carolina, Clemson · 7.20 mi from centre
8.2
930 reviews
Breakfast available
With a stay at Comfort Inn & Suites Clemson - University Area in Clemson, you'll be within a 5-minute drive of Clemson University and Lake Hartwell. This hotel is 8 mi (12.8 km) from Lake Keowee and 0.4 mi (0.7 km) from AnMed Health.

Hotel in Upstate South Carolina, Clemson · 7.27 mi from centre
8.2
901 reviews
Breakfast available
With a stay at Best Western Plus Clemson Hotel & Conference Center in Clemson, you'll be within a 5-minute drive of Clemson University and Lake Hartwell. This hotel is 8.1 mi (13.1 km) from Lake Keowee and 0.3 mi (0.5 km) from Clemson Area African American Museum.

Hotel in Upstate South Carolina, Clemson · 7.66 mi from centre
7.9
179 reviews
Holiday Inn Express Hotel & Suites Clemson - University Area by IHG is located in Clemson, 2.5 miles from Clemson Memorial Stadium and 27 miles from Fluor Field. With a fitness center, the 2-star hotel has air-conditioned rooms with free WiFi, each with a private bathroom. The property provides a shared lounge, a 24-hour front desk and luggage storage for guests.
At the hotel, the rooms have a desk. Each room is equipped with a coffee machine, while some rooms are equipped with a kitchenette with a fridge and a microwave. Guest rooms in Holiday Inn Express Hotel & Suites Clemson - University Area by IHG are equipped with a flat-screen TV and free toiletries.
A buffet breakfast is available at the accommodation.
Peace Center is 28 miles from Holiday Inn Express Hotel & Suites Clemson - University Area by IHG, while Sirrine Stadium is 28 miles away. Greenville-Spartanburg International Airport is 41 miles from the property.

Hotel in Upstate South Carolina, Clemson · 7.67 mi from centre
8.8
857 reviews
Breakfast available
With a stay at Holiday Inn Express & Suites Clemson by IHG, you'll be centrally located in Clemson, a 3-minute drive from Lake Hartwell and 5 minutes from Clemson University. This hotel is 8.6 mi (13.8 km) from Lake Keowee and 0.9 mi (1.5 km) from Clemson Area African American Museum.

Hotel in Upstate South Carolina, Clemson · 7.94 mi from centre
8.4
48 reviews
Courtyard Clemson has a seasonal outdoor swimming pool, fitness center, a shared lounge and restaurant in Clemson. This 3-star hotel offers a 24-hour front desk and a business center. Guests can use a bar.
À la carte and American breakfast options are available at the hotel.
Clemson Memorial Stadium is 2.4 miles from Courtyard Clemson, while Fluor Field is 27 miles from the property. Greenville-Spartanburg International Airport is 41 miles away.

Condominium resort in Upstate South Carolina, Townville · 10.09 mi from centre
7.6
10 reviews
With a stay at The Point RV in Townville, you'll be within a 15-minute drive of Lake Hartwell and Townville Landing. This condominium resort is 12.5 mi (20.2 km) from Clemson University and 14.8 mi (23.7 km) from Lake Keowee.

Bed & breakfast in Upstate South Carolina, Pendleton · 10.15 mi from centre
9.8
50 reviews
Breakfast available
When you stay at Liberty Hall Bed and Breakfast in Pendleton, you'll be in a state park, within a 10-minute drive of Clemson University and Lake Hartwell. This bed & breakfast is 14 mi (22.5 km) from Lake Keowee and 0.6 mi (1 km) from Pendleton District Commission.

Vacation home in Upstate South Carolina, Pendleton · 10.46 mi from centre
With a stay at this vacation home in Pendleton, you'll be within a 10-minute drive of Clemson University and Lake Hartwell. This vacation home is 13 mi (20.9 km) from Lake Keowee and 0.9 mi (1.4 km) from Tri-County Technical College.

Apartment in Oconee County, Salem · 10.53 mi from centre
9.0
1 review
Boat, Golf and Swim Keowee Key Condo with Lake Views offers accommodations in Salem, 16 miles from Clemson Memorial Stadium. Free Wifi is provided throughout the property and private parking is available on site. The accommodation provides a 24-hour front desk and an elevator for guests.
Providing a balcony with lake views, this apartment also offers a cable flat-screen TV, a well-equipped kitchen with a dishwasher, an oven, and a microwave, as well as 2 bathrooms with a bath and a hair dryer. The property has an outdoor dining area.
The apartment conveniently has an outdoor pool.
Greenville-Spartanburg International Airport is 50 miles away.

Hotel in Oconee County, Westminster · 8.33 mi from centre
5.4
26 reviews
Located in Westminster, Relax Inn Westminster is within a 15-minute drive of Applewood Shopping Center and Oconee Memorial Hospital. This hotel is 9.1 mi (14.7 km) from Lake Keowee and 9.9 mi (15.9 km) from Lake Hartwell.